We call a closed, connected, orientable manifold in one of the categories TOP, PL or
DIFF chiral if it does not admit an orientation-reversing automorphism and
amphicheiral otherwise. Moreover, we call a manifold strongly chiral if it does not
admit a self-map of degree −1. We prove that there are strongly chiral, smooth
manifolds in every oriented bordism class in every dimension ≥ 3. We also produce
simply-connected, strongly chiral manifolds in every dimension ≥ 7. For every k ≥ 1,
we exhibit lens spaces with an orientation-reversing self-diffeomorphism of order 2k
but no self-map of degree −1 of smaller order.